2-THENYLACETIC ACID
2-Thiopheneacetic acid
CAS: 1918-77-0
Molecular Formula: C6H6O2S
2-THENYLACETIC ACID - Names and Identifiers
2-THENYLACETIC ACID - Physico-chemical Properties
| Molecular Formula | C6H6O2S |
| Molar Mass | 142.18 |
| Density | 1.365 (estimate) |
| Melting Point | 63-64 °C (lit.) |
| Boling Point | 160 °C/22 mmHg (lit.) |
| Flash Point | 160°C/22mm |
| Water Solubility | Soluble in water, ethanol, ether and carbon tetrachloride. |
| Vapor Presure | 0.00363mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Slightly brown to brown |
| BRN | 114551 |
| pKa | 4.23±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.5300 (estimate) |
| Physical and Chemical Properties | Melting Point 61-65°C boiling point 160°C (22 mmHg) |
| Use | Used as cefotaxime, cefalotin sodium and other drug intermediates |
2-THENYLACETIC ACID - Risk and Safety
| Risk Codes | R34 - Causes burns R37 - Irritating to the respiratory system R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29349990 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | III |
2-THENYLACETIC ACID - Upstream Downstream Industry
| Raw Materials | Thiophene |
2-THENYLACETIC ACID - Nature
Open Data Verified Data
white or yellowish scaly crystals. Boiling point of 160 deg C (2. 93kPa). Melting point 76 °c. Soluble in water, ethanol, ethyl ether and carbon tetrachloride.
Last Update：2025-06-10 22:55:16
2-THENYLACETIC ACID - Preparation Method
Open Data Verified Data
thiophene was acetylated with acetic anhydride in 85% Phosphoric acid to obtain 2 acetyl thiophene. 2 A acetyl thiophene and 95% ethanol, sulfur powder, ammonia water under pressure to generate 2 a thiophene acetamide, and then hydrolyzed, refined, 2 A thiophene acetic acid.
Acetyl thiophene acidification method of acetyl thiophene in boron trifluoride catalyst with tetraacetic acid lead for oxidation rearrangement of carboxylate, and hydrolysis of 2 thiophene acetic acid.
Last Update：2022-01-01 10:57:57
2-THENYLACETIC ACID - Application
Open Data Verified Data
pharmaceutical intermediates for the preparation of cephalosporin I No. And cephalosporin II.
Last Update：2025-08-19 16:24:40
2-THENYLACETIC ACID - Safety
Open Data Verified Data
- toxic. See thiophene for toxicity and protection methods.
- glass bottle external carton packaging. Take it lightly to avoid collision. Protection against heat and sun. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2025-06-10 22:55:16
2-THENYLACETIC ACID - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | This product is an intermediate of cephalosporin I and II. used as drug intermediates of cefotaxime and cefalotin sodium thiophene -2-acetic acid is an intermediate of cephalosporins cephalosporin Ⅰ and cephalosporin Ⅱ. |
| production method | thiophene is acetylated with acetic anhydride in 85% Phosphoric acid to give 2-acetylthiophene. 2-acetyl thiophene, 95% ethanol, sulfur powder and ammonia at 140 ℃, 1. 4mpa into 2-thiophene acetamide, then add hydrochloric acid at 80-90 ℃ hydrolysis for 1.5h, after purification, 2-thiopheneacetic acid was obtained. |
Last Update：2024-04-10 22:29:15
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Raw Materials for 2-THENYLACETIC ACID